The house itself is very distinctive. It is painted pink, with a red roof, and the words "KAME HOUSE" are displayed prominently on the front of the upper story.
It appears to be a prefabricated building, as it can be capsulized and relocated with ease. When Goku and Kuririn begin their training under Roshi, he places the house inside a capsule and moves it to a larger island. Some time after the 21st Tenka'ichi Budôkai takes place, Kame House is apparently moved back to its original location.
During the King Piccolo Saga, Kame House is moved again, in order to hide it from Piccolo Daimao's henchman Tambourine. Eventually Tambourine does locate it, although ironically he had stopped to ask directions to the original island. He fights the injured Yamucha, but is forced to leave before he can kill his target. In addition, the appearance of the small island on which Kame House is usually situated changes several times throughout the series. It can be presumed that the house is relocated to different islands for reasons unknown.